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Blood Lipid Test May Predict Treatment Success in Advanced Prostate Cancer

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Blood Lipid Test May Predict Treatment Success in Advanced Prostate Cancer

Prostate cancer that spreads beyond the prostate but still responds to hormone treatment is called metastatic hormone-sensitive prostate cancer (mHSPC). The drug enzalutamide is often used to extend life in these patients. Yet, not everyone benefits equally from this treatment. A new study suggests that a simple blood test may help doctors predict which men will respond best.

Researchers analyzed blood samples from 866 men who took part in the large ENZAMET trial. They looked at a special lipid (fat) pattern in the blood, known as PCPro. About 13% of the men had a positive PCPro result before starting treatment.

The study found that men with a positive PCPro result had worse outcomes. They lived for a shorter time and their cancer progressed sooner than those with a negative PCPro result. Even after accounting for other known risk factors, PCPro remained a strong predictor of poor survival.

Interestingly, enzalutamide helped men with a negative PCPro result live longer, but it did not improve survival in men who were PCPro positive. This means the PCPro blood test could help identify patients who might need different or additional treatments.

The researchers say PCPro could become an important biomarker to guide treatment decisions. Future studies may test whether changing lipid levels in the blood can improve outcomes for men with advanced prostate cancer.

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