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HPV Vaccination After Conisation May Lower Risk of Precancer Coming Back

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HPV Vaccination After Conisation May Lower Risk of Precancer Coming Back

Cervical cancer is often caused by long-lasting infection with certain types of human papillomavirus (HPV). Many women with high-grade precancerous changes, known as CIN 2 or CIN 3, need a procedure called conisation to remove the abnormal cells. While this treatment works well, there is still a chance the abnormal cells can return.

A new review looked at whether getting the HPV vaccine before, during, or after conisation could lower that risk. Researchers analyzed 13 studies involving more than 21,000 women from several countries. Most of these studies compared women who received the HPV vaccine with those who did not after conisation.

The results showed that HPV vaccination reduced the chance of the abnormal cells returning. Women who were vaccinated had about half the risk of developing new or recurrent high-grade changes (CIN 2+). The benefit appeared strongest against HPV types 16 and 18, which cause most cervical cancers.

The review also found that the vaccine was safe, with only minor side effects such as redness or mild headache. However, the researchers noted that most of the available studies were not randomized clinical trials, so the certainty of the evidence remains low.

Even so, these findings suggest that HPV vaccination around the time of conisation may help prevent future HPV-related cell changes. More high-quality studies are needed, but vaccination could become an important part of care for women treated for precancerous cervical lesions.

DOI: 10.1002/14651858.CD016121

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