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Common Blood Pressure Medicines May Improve Survival in Esophageal Cancer

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Common Blood Pressure Medicines May Improve Survival in Esophageal Cancer

Esophageal adenocarcinoma is often treated with a combination of chemotherapy, radiation, and surgery. While these treatments can be effective, doctors are also exploring whether other commonly used medicines might help improve survival.

A new study looked at patients with locally advanced esophageal adenocarcinoma who were treated between 2002 and 2017. Researchers focused on people who happened to be taking angiotensin system inhibitors—a type of medication often prescribed for high blood pressure and heart conditions.

Out of 375 patients, about one in four were taking these medicines during their cancer treatment. The results showed that patients on angiotensin system inhibitors lived much longer:

– Overall survival:
59 months vs. 30 months for non-users
– Disease-free survival (time without cancer returning): 26 months vs. 18 months for non-users

Even after adjusting for age and other health problems, the survival advantage remained. These medicines did not appear to make tumors shrink more before surgery, but they did seem to improve long-term outcomes.

This study suggests that a class of drugs already widely used for blood pressure may also have benefits in cancer care. More research is needed to confirm these results, but for patients already taking these medicines, the findings may be encouraging.

Patients with esophageal cancer should not start or stop any medication without talking to their doctor, but this research opens the door to repurposing existing medicines to improve cancer survival.

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